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Ghostbusters: Afterlife is a 2021 American supernatural comedy film directed by Jason Reitman, who co-wrote the screenplay with Gil Kenan. The film stars Carrie Coon, Finn Wolfhard, Mckenna Grace and Paul Rudd, while Bill Murray, Dan Aykroyd, Ernie Hudson, Sigourney Weaver and Annie Potts reprise their roles from the original films. It is the sequel to Ghostbusters (1984) and Ghostbusters II (1989) and the fourth film overall in the Ghostbusters franchise. Set thirty years after the events of the second film, a single mother and her two children move to a small town in Oklahoma, where they discover their connection to the original Ghostbusters and their grandfather's secret legacy.

A third Ghostbusters film had been in various stages of development since Ghostbusters II released in 1989, stalling as Murray refused to commit to the project. After the death of cast member Harold Ramis in 2014, Sony instead produced a reboot released in 2016. The film performed poorly at the box office, and Reitman began developing a sequel to the original films. The new cast members were announced by July 2019, while the original cast signed on two months later. Filming took place from July to October 2019.

Ghostbusters: Afterlife was screened unannounced on August 23, 2021 during the 2021 CinemaCon event in Los Angeles, and is scheduled to be released in the United States on November 19, 2021, after being delayed four times from an original July 2020 date due to the COVID-19 pandemic.